It'd also most likely mean to drop multilibs from the x86_64 repo by default
...so you're going to drop wine? (At least, besides doing some funky chroot magic to install it?)
There is actually 64 bit support in wine now. I've vaguely wondered whether we'll support it but not enough to bother to file a bug as all the apps I use with it are 32 bit anyway (and then wine has to also support WoW (Windows on Windows....... love the name!) which I doubt they do).
Peter