I have vdsm.conf set for ssl=true.   When I run vdsClient from localhost, I get connection refused.

# vdsClient -s localhost list table
Connection to localhost:54321 refused
# vdsClient -s 0 list table
Connection to 172.249.6.135:54321 refused

My host IPADDR is set to a 10. address internally, but I have added an external secondary address to the nic.

# ip addr show 
6: xxxx: <BROADCAST,MULTICAST,UP,LOWER_UP> mtu 1500 qdisc noqueue state UNKNOWN 
    link/ether 14:fe:b5:ca:5a:78 brd ff:ff:ff:ff:ff:ff
    inet 10.249.6.135/24 brd 10.249.6.255 scope global rhevm
    inet 172.249.6.135/24 scope global rhevm

From a remote host, the vdsClient works okay.

# vdsClient -s 172.249.6.135 list table
86e03987-8d54-4d1b-af39-85200b959e2f   7268  rh5-royal            Up                                       

My question, what could cause ECONNREFUSED from a localhost?

I got this from strace:
16:36:49 connect(3, {sa_family=AF_INET, sin_port=htons(54321), sin_addr=inet_addr("172.249.6.135")}, 16) = -1 ECONNREFUSED (Connection refused) <0.000439>