"Is there a concern or known issue that will cause systemd-resolved to
not work in your setup?"
I have a ton of experience with sssd and before that samba winbind so know the benefits and limitations of this software stack well. I'm new to systemd-resolved but have been reading the lively Fedora threads about it and think it could still do with some further improvements, which I'm sure will occur in the goodness of time, but as it stands right now the argument to jump to it isn't compelling enough for me.
nscd may be old and decrepit but it's still delivering the goods.