Happened again, I did this "modprobe -r uhci_hcd ; modprobe uhci_hcd".  The mouse came back to life but the PS/2 keyboard died.

Great :(

On Wed, 2004-09-01 at 10:15 +0900, Naoki wrote:
Hi all,

    With kernel 2.6.8-1.533 my USB mouse will stop working any where between half an hour and a couple of hours after a boot.
Can't quite remember which module is handling it (uhci_hcd?).  How do I reload this without losing the keyboard as well ?

The mouse is a logitech MX500 and the light stays on.

-n.